Harvard Mental Health Letter - Questions & Answers.

Q. Does the new antidepressant duloxetine (Cymbalta) have any advantages over other antidepressant drugs?
A. Duloxetine (Cymbalta) became available by prescription in the summer of 2004. Described as a selective serotonin and norepinephrine reuptake inhibitor (SSNRI), it boosts the activity of two neurotransmitters that play a role in depression.

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Dual-action medications already available include older tricyclic antidepressants and two more recent drugs, venlafaxine (Effexor) and mirtazapine (Remeron). Especially for patients with moderate to severe depression, dual-action drugs may work better than the popular antidepressants that …
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